Tripolin A

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Tripolin A 是 Aurora A 激酶的特异性非 ATP 竞争性抑制剂（Aurora A 和 Aurora B 的 IC50 值分别为 1.5 μM 和 7 μM）。

Tripolin A is a specific non-ATP competitive inhibitor of Aurora A kinase(Aurora A and Aurora B with IC50 values of 1.5 μM and 7 μM, respectively)Tripolin A, a non-ATP competitive inhibitor.?Tripolin A reduced the localization of pAurora A on spindle microtubules (MTs), affected centrosome integrity, spindle formation and length, as well as MT dynamics in interphase, consistent with Aurora A inhibition by RNAi or other specific inhibitors, such as MLN8054 or MLN8237.?Interestingly, Tripolin A affected the gradient distribution towards the chromosomes, but not the MT binding of HURP (Hepatoma Up-Regulated Protein), a MT-associated protein (MAP) and substrate of the Aurora A kinase.?Therefore Tripolin A reveals a new way of regulating mitotic MT stabilizers through Aurora A phosphorylation.?

Tripolin A induces mitotic spindle defects and spindle pole abnormalities.

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Cell Cycle/DNA Damage

Aurora Kinase

Aurora A

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1148118-92-6

253.25

C15H11NO3

>98% (HPLC)

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Oc3cc(/C=C1\c2ccccc2NC1=O)c(O)cc3

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(-20℃)

With Ice Pack

≥ 2 years